CovidSeniorV1, Main, Exploration, bibRecord, 000198

Study protocol for the COPE study: COVID-19 in Older PEople: the influence of frailty and multimorbidity on survival. A multicentre, European observational study.

Identifieur interne : 000198 ( Main/Exploration ); précédent : 000197; suivant : 000199

Study protocol for the COPE study: COVID-19 in Older PEople: the influence of frailty and multimorbidity on survival. A multicentre, European observational study.

Auteurs : Angeline Price [Royaume-Uni] ; Fenella Barlow-Pay [Royaume-Uni] ; Siobhan Duffy [Royaume-Uni] ; Lyndsay Pearce [Royaume-Uni] ; Arturo Vilches-Moraga [Royaume-Uni] ; Susan Moug [Royaume-Uni] ; Terry Quinn [Royaume-Uni] ; Michael Stechman [Royaume-Uni] ; Philip Braude [Royaume-Uni] ; Emma Mitchell [Royaume-Uni] ; Phyo Kyaw Myint [Royaume-Uni] ; Alessia Verduri [Italie] ; Kathryn Mccarthy [Royaume-Uni] ; Ben Carter [Royaume-Uni] ; Jonathan Hewitt [Royaume-Uni]

Source :

BMJ open [ 2044-6055 ] ; 2020.

RBID : pubmed:32994260

Descripteurs français

KwdFr :
- Adulte (MeSH), Analyse de survie (MeSH), Betacoronavirus (isolement et purification), Corrélation de données (MeSH), Europe (épidémiologie), Femelle (MeSH), Fragilité (diagnostic), Fragilité (épidémiologie), Hospitalisation (statistiques et données numériques), Humains (MeSH), Infections à coronavirus (diagnostic), Infections à coronavirus (mortalité), Infections à coronavirus (thérapie), Multimorbidité (MeSH), Mâle (MeSH), Pandémies (MeSH), Personne âgée fragile (psychologie), Personne âgée fragile (statistiques et données numériques), Pneumopathie virale (diagnostic), Pneumopathie virale (mortalité), Pneumopathie virale (thérapie), Qualité de vie (MeSH), Santé publique (méthodes), Sujet âgé (MeSH), Études multicentriques comme sujet (MeSH), Études observationnelles comme sujet (MeSH), Évaluation gériatrique (méthodes).
MESH :
- diagnostic : Fragilité, Infections à coronavirus, Pneumopathie virale.
- isolement et purification : Betacoronavirus.
- mortalité : Infections à coronavirus, Pneumopathie virale.
- méthodes : Santé publique, Évaluation gériatrique.
- psychologie : Personne âgée fragile.
- statistiques et données numériques : Hospitalisation, Personne âgée fragile.
- thérapie : Infections à coronavirus, Pneumopathie virale.
- épidémiologie : Europe, Fragilité.
- Adulte, Analyse de survie, Corrélation de données, Femelle, Humains, Multimorbidité, Mâle, Pandémies, Qualité de vie, Sujet âgé, Études multicentriques comme sujet, Études observationnelles comme sujet.

English descriptors

KwdEn :
- Adult (MeSH), Aged (MeSH), Betacoronavirus (isolation & purification), Coronavirus Infections (diagnosis), Coronavirus Infections (mortality), Coronavirus Infections (therapy), Correlation of Data (MeSH), Europe (epidemiology), Female (MeSH), Frail Elderly (psychology), Frail Elderly (statistics & numerical data), Frailty (diagnosis), Frailty (epidemiology), Geriatric Assessment (methods), Hospitalization (statistics & numerical data), Humans (MeSH), Male (MeSH), Multicenter Studies as Topic (MeSH), Multimorbidity (MeSH), Observational Studies as Topic (MeSH), Pandemics (MeSH), Pneumonia, Viral (diagnosis), Pneumonia, Viral (mortality), Pneumonia, Viral (therapy), Public Health (methods), Quality of Life (MeSH), Survival Analysis (MeSH).
MESH :
- geographic , epidemiology : Europe.
- diagnosis : Coronavirus Infections, Frailty, Pneumonia, Viral.
- epidemiology : Frailty.
- isolation & purification : Betacoronavirus.
- methods : Geriatric Assessment, Public Health.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- psychology : Frail Elderly.
- statistics & numerical data : Frail Elderly, Hospitalization.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- Adult, Aged, Correlation of Data, Female, Humans, Male, Multicenter Studies as Topic, Multimorbidity, Observational Studies as Topic, Pandemics, Quality of Life, Survival Analysis.

Abstract

INTRODUCTION

This protocol describes an observational study which set out to assess whether frailty and/or multimorbidity correlates with short-term and medium-term outcomes in patients diagnosed with COVID-19 in a European, multicentre setting.

METHODS AND ANALYSIS

Over a 3-month period we aim to recruit a minimum of 500 patients across 10 hospital sites, collecting baseline data including: patient demographics; presence of comorbidities; relevant blood tests on admission; prescription of ACE inhibitors/angiotensin receptor blockers/non-steroidal anti-inflammatory drugs/immunosuppressants; smoking status; Clinical Frailty Score (CFS); length of hospital stay; mortality and readmission. All patients receiving inpatient hospital care >18 years who receive a diagnosis of COVID-19 are eligible for inclusion. Long-term follow-up at 6 and 12 months is planned. This will assess frailty, quality of life and medical complications.Our primary analysis will be short-term and long-term mortality by CFS, adjusted for age (18-64, 65-80 and >80) and gender. We will carry out a secondary analysis of the primary outcome by including additional clinical mediators which are determined statistically important using a likelihood ratio test. All analyses will be presented as crude and adjusted HR and OR with associated 95% CIs and p values.

ETHICS AND DISSEMINATION

This study has been registered, reviewed and approved by the following: Health Research Authority (20/HRA1898); Ethics Committee of Hospital Policlinico Modena, Italy (369/2020/OSS/AOUMO); Health and Care Research Permissions Service, Wales; and NHS Research Scotland Permissions Co-ordinating Centre, Scotland. All participating units obtained approval from their local Research and Development department consistent with the guidance from their relevant national organisation.Data will be reported as a whole cohort. This project will be submitted for presentation at a national or international surgical and geriatric conference. Manuscript(s) will be prepared following the close of the project.

DOI: 10.1136/bmjopen-2020-040569
PubMed: 32994260
PubMed Central: PMC7526029

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000049
to stream Main, to step Curation: 000049

Le document en format XML

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<author><name sortKey="Vilches Moraga, Arturo" sort="Vilches Moraga, Arturo" uniqKey="Vilches Moraga A" first="Arturo" last="Vilches-Moraga">Arturo Vilches-Moraga</name>
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<author><name sortKey="Stechman, Michael" sort="Stechman, Michael" uniqKey="Stechman M" first="Michael" last="Stechman">Michael Stechman</name>
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<author><name sortKey="Braude, Philip" sort="Braude, Philip" uniqKey="Braude P" first="Philip" last="Braude">Philip Braude</name>
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<author><name sortKey="Mitchell, Emma" sort="Mitchell, Emma" uniqKey="Mitchell E" first="Emma" last="Mitchell">Emma Mitchell</name>
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<author><name sortKey="Myint, Phyo Kyaw" sort="Myint, Phyo Kyaw" uniqKey="Myint P" first="Phyo Kyaw" last="Myint">Phyo Kyaw Myint</name>
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<author><name sortKey="Verduri, Alessia" sort="Verduri, Alessia" uniqKey="Verduri A" first="Alessia" last="Verduri">Alessia Verduri</name>
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<author><name sortKey="Hewitt, Jonathan" sort="Hewitt, Jonathan" uniqKey="Hewitt J" first="Jonathan" last="Hewitt">Jonathan Hewitt</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Betacoronavirus (isolation & purification)</term>
<term>Coronavirus Infections (diagnosis)</term>
<term>Coronavirus Infections (mortality)</term>
<term>Coronavirus Infections (therapy)</term>
<term>Correlation of Data (MeSH)</term>
<term>Europe (epidemiology)</term>
<term>Female (MeSH)</term>
<term>Frail Elderly (psychology)</term>
<term>Frail Elderly (statistics & numerical data)</term>
<term>Frailty (diagnosis)</term>
<term>Frailty (epidemiology)</term>
<term>Geriatric Assessment (methods)</term>
<term>Hospitalization (statistics & numerical data)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Multicenter Studies as Topic (MeSH)</term>
<term>Multimorbidity (MeSH)</term>
<term>Observational Studies as Topic (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (diagnosis)</term>
<term>Pneumonia, Viral (mortality)</term>
<term>Pneumonia, Viral (therapy)</term>
<term>Public Health (methods)</term>
<term>Quality of Life (MeSH)</term>
<term>Survival Analysis (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Analyse de survie (MeSH)</term>
<term>Betacoronavirus (isolement et purification)</term>
<term>Corrélation de données (MeSH)</term>
<term>Europe (épidémiologie)</term>
<term>Femelle (MeSH)</term>
<term>Fragilité (diagnostic)</term>
<term>Fragilité (épidémiologie)</term>
<term>Hospitalisation (statistiques et données numériques)</term>
<term>Humains (MeSH)</term>
<term>Infections à coronavirus (diagnostic)</term>
<term>Infections à coronavirus (mortalité)</term>
<term>Infections à coronavirus (thérapie)</term>
<term>Multimorbidité (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Personne âgée fragile (psychologie)</term>
<term>Personne âgée fragile (statistiques et données numériques)</term>
<term>Pneumopathie virale (diagnostic)</term>
<term>Pneumopathie virale (mortalité)</term>
<term>Pneumopathie virale (thérapie)</term>
<term>Qualité de vie (MeSH)</term>
<term>Santé publique (méthodes)</term>
<term>Sujet âgé (MeSH)</term>
<term>Études multicentriques comme sujet (MeSH)</term>
<term>Études observationnelles comme sujet (MeSH)</term>
<term>Évaluation gériatrique (méthodes)</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Europe</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term>
<term>Frailty</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Fragilité</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Frailty</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Geriatric Assessment</term>
<term>Public Health</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Santé publique</term>
<term>Évaluation gériatrique</term>
</keywords>
<keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Personne âgée fragile</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Frail Elderly</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Frail Elderly</term>
<term>Hospitalization</term>
</keywords>
<keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Hospitalisation</term>
<term>Personne âgée fragile</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Europe</term>
<term>Fragilité</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Correlation of Data</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Multicenter Studies as Topic</term>
<term>Multimorbidity</term>
<term>Observational Studies as Topic</term>
<term>Pandemics</term>
<term>Quality of Life</term>
<term>Survival Analysis</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Analyse de survie</term>
<term>Corrélation de données</term>
<term>Femelle</term>
<term>Humains</term>
<term>Multimorbidité</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Qualité de vie</term>
<term>Sujet âgé</term>
<term>Études multicentriques comme sujet</term>
<term>Études observationnelles comme sujet</term>
</keywords>
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<front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b>
</p>
<p>This protocol describes an observational study which set out to assess whether frailty and/or multimorbidity correlates with short-term and medium-term outcomes in patients diagnosed with COVID-19 in a European, multicentre setting.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS AND ANALYSIS</b>
</p>
<p>Over a 3-month period we aim to recruit a minimum of 500 patients across 10 hospital sites, collecting baseline data including: patient demographics; presence of comorbidities; relevant blood tests on admission; prescription of ACE inhibitors/angiotensin receptor blockers/non-steroidal anti-inflammatory drugs/immunosuppressants; smoking status; Clinical Frailty Score (CFS); length of hospital stay; mortality and readmission. All patients receiving inpatient hospital care >18 years who receive a diagnosis of COVID-19 are eligible for inclusion. Long-term follow-up at 6 and 12 months is planned. This will assess frailty, quality of life and medical complications.Our primary analysis will be short-term and long-term mortality by CFS, adjusted for age (18-64, 65-80 and >80) and gender. We will carry out a secondary analysis of the primary outcome by including additional clinical mediators which are determined statistically important using a likelihood ratio test. All analyses will be presented as crude and adjusted HR and OR with associated 95% CIs and p values.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>ETHICS AND DISSEMINATION</b>
</p>
<p>This study has been registered, reviewed and approved by the following: Health Research Authority (20/HRA1898); Ethics Committee of Hospital Policlinico Modena, Italy (369/2020/OSS/AOUMO); Health and Care Research Permissions Service, Wales; and NHS Research Scotland Permissions Co-ordinating Centre, Scotland. All participating units obtained approval from their local Research and Development department consistent with the guidance from their relevant national organisation.Data will be reported as a whole cohort. This project will be submitted for presentation at a national or international surgical and geriatric conference. Manuscript(s) will be prepared following the close of the project.</p>
</div>
</front>
</TEI>
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<DateCompleted><Year>2020</Year>
<Month>10</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>10</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2044-6055</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>10</Volume>
<Issue>9</Issue>
<PubDate><Year>2020</Year>
<Month>09</Month>
<Day>29</Day>
</PubDate>
</JournalIssue>
<Title>BMJ open</Title>
<ISOAbbreviation>BMJ Open</ISOAbbreviation>
</Journal>
<ArticleTitle>Study protocol for the COPE study: COVID-19 in Older PEople: the influence of frailty and multimorbidity on survival. A multicentre, European observational study.</ArticleTitle>
<Pagination><MedlinePgn>e040569</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1136/bmjopen-2020-040569</ELocationID>
<Abstract><AbstractText Label="INTRODUCTION">This protocol describes an observational study which set out to assess whether frailty and/or multimorbidity correlates with short-term and medium-term outcomes in patients diagnosed with COVID-19 in a European, multicentre setting.</AbstractText>
<AbstractText Label="METHODS AND ANALYSIS">Over a 3-month period we aim to recruit a minimum of 500 patients across 10 hospital sites, collecting baseline data including: patient demographics; presence of comorbidities; relevant blood tests on admission; prescription of ACE inhibitors/angiotensin receptor blockers/non-steroidal anti-inflammatory drugs/immunosuppressants; smoking status; Clinical Frailty Score (CFS); length of hospital stay; mortality and readmission. All patients receiving inpatient hospital care >18 years who receive a diagnosis of COVID-19 are eligible for inclusion. Long-term follow-up at 6 and 12 months is planned. This will assess frailty, quality of life and medical complications.Our primary analysis will be short-term and long-term mortality by CFS, adjusted for age (18-64, 65-80 and >80) and gender. We will carry out a secondary analysis of the primary outcome by including additional clinical mediators which are determined statistically important using a likelihood ratio test. All analyses will be presented as crude and adjusted HR and OR with associated 95% CIs and p values.</AbstractText>
<AbstractText Label="ETHICS AND DISSEMINATION">This study has been registered, reviewed and approved by the following: Health Research Authority (20/HRA1898); Ethics Committee of Hospital Policlinico Modena, Italy (369/2020/OSS/AOUMO); Health and Care Research Permissions Service, Wales; and NHS Research Scotland Permissions Co-ordinating Centre, Scotland. All participating units obtained approval from their local Research and Development department consistent with the guidance from their relevant national organisation.Data will be reported as a whole cohort. This project will be submitted for presentation at a national or international surgical and geriatric conference. Manuscript(s) will be prepared following the close of the project.</AbstractText>
<CopyrightInformation>© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Price</LastName>
<ForeName>Angeline</ForeName>
<Initials>A</Initials>
<Identifier Source="ORCID">0000-0002-4674-270X</Identifier>
<AffiliationInfo><Affiliation>Ageing and Complex Medicine, Salford Royal NHS Trust, Salford, UK angeline.price@srft.nhs.uk.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Barlow-Pay</LastName>
<ForeName>Fenella</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Anaesthetics, Royal Alexandra Hospital, Paisley, Renfrewshire, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Duffy</LastName>
<ForeName>Siobhan</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>General Surgery, Royal Alexandra Hospital, Paisley, Renfrewshire, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pearce</LastName>
<ForeName>Lyndsay</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>General Surgery, Salford Royal NHS Foundation Trust, Salford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vilches-Moraga</LastName>
<ForeName>Arturo</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Ageing and Complex Medicine, Salford Royal NHS Trust, Salford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moug</LastName>
<ForeName>Susan</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>General Surgery, Royal Alexandra Hospital, Paisley, Renfrewshire, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>University of Glasgow, Glasgow, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Quinn</LastName>
<ForeName>Terry</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stechman</LastName>
<ForeName>Michael</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>General Surgery, University Hospital of Wales, Cardiff, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Braude</LastName>
<ForeName>Philip</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Medicine for Older People, North Bristol NHS Trust, Westbury on Trym, Bristol, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mitchell</LastName>
<ForeName>Emma</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Medicine for Older People, North Bristol NHS Trust, Westbury on Trym, Bristol, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Myint</LastName>
<ForeName>Phyo Kyaw</ForeName>
<Initials>PK</Initials>
<Identifier Source="ORCID">0000-0003-3852-6158</Identifier>
<AffiliationInfo><Affiliation>University of Aberdeen, Aberdeen, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Verduri</LastName>
<ForeName>Alessia</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Hospital Policlinico Modena, Modena, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McCarthy</LastName>
<ForeName>Kathryn</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>General Surgery, North Bristol NHS Trust, Bristol, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Carter</LastName>
<ForeName>Ben</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Biostatistics and Health Informatics, King's College London, London, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>King's College London, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hewitt</LastName>
<ForeName>Jonathan</ForeName>
<Initials>J</Initials>
<Identifier Source="ORCID">0000-0002-7924-1792</Identifier>
<AffiliationInfo><Affiliation>Geriatric Medicine, Cardiff University, Cardiff, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>COPE Study Collaborators</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D000078325">Clinical Trial Protocol</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>09</Month>
<Day>29</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>BMJ Open</MedlineTA>
<NlmUniqueID>101552874</NlmUniqueID>
<ISSNLinking>2044-6055</ISSNLinking>
</MedlineJournalInfo>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="Y">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000078331" MajorTopicYN="N">Correlation of Data</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005060" MajorTopicYN="N" Type="Geographic">Europe</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016330" MajorTopicYN="Y">Frail Elderly</DescriptorName>
<QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073496" MajorTopicYN="Y">Frailty</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015577" MajorTopicYN="N">Geriatric Assessment</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015337" MajorTopicYN="N">Multicenter Studies as Topic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000076322" MajorTopicYN="Y">Multimorbidity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D064887" MajorTopicYN="N">Observational Studies as Topic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="Y">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011634" MajorTopicYN="N">Public Health</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011788" MajorTopicYN="Y">Quality of Life</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">geriatric medicine</Keyword>
<Keyword MajorTopicYN="Y">health policy</Keyword>
<Keyword MajorTopicYN="Y">public health</Keyword>
</KeywordList>
<CoiStatement>Competing interests: None declared.</CoiStatement>
<InvestigatorList><Investigator ValidYN="Y"><LastName>Davey</LastName>
<ForeName>Charlotte</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Jones</LastName>
<ForeName>Sheila</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lunstone</LastName>
<ForeName>Kiah</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cavenagh</LastName>
<ForeName>Alice</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Silver</LastName>
<ForeName>Charlotte</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Telford</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Simmons</LastName>
<ForeName>Rebecca</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Singh</LastName>
<ForeName>Sandeep</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Paxton</LastName>
<ForeName>Dolcie</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rickard</LastName>
<ForeName>Francis</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Holloway</LastName>
<ForeName>Mark</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hesford</LastName>
<ForeName>James</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Jichi</LastName>
<ForeName>Tarik</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Galbraith</LastName>
<ForeName>Norman</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Edwards</LastName>
<ForeName>Jenny</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bhatti</LastName>
<ForeName>Emma</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bisset</LastName>
<ForeName>Carly</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Alexander</LastName>
<ForeName>Ross</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ingham</LastName>
<ForeName>Abigail</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Short</LastName>
<ForeName>Roxanna</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>McGovern</LastName>
<ForeName>Aine</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Collins</LastName>
<ForeName>Jemima</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bruce</LastName>
<ForeName>Eilidh</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Einarsson</LastName>
<ForeName>Alice</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Clini</LastName>
<ForeName>Enrico</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Guaraldi</LastName>
<ForeName>Giovanni</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Garcia</LastName>
<ForeName>Madeline</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sangani</LastName>
<ForeName>Shefali</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Kneen</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Kyriakopoulos</LastName>
<ForeName>George</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Thomas</LastName>
<ForeName>Michael</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Tan</LastName>
<ForeName>Denise</ForeName>
<Initials>D</Initials>
</Investigator>
</InvestigatorList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>9</Month>
<Day>30</Day>
<Hour>6</Hour>
<Minute>6</Minute>
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<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>10</Month>
<Day>1</Day>
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<Minute>0</Minute>
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Study protocol for the COPE study: COVID-19 in Older PEople: the influence of frailty and multimorbidity on survival. A multicentre, European observational study.

Study protocol for the COPE study: COVID-19 in Older PEople: the influence of frailty and multimorbidity on survival. A multicentre, European observational study.

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